Table 2. Clinical and pathologic features of patient material established animal models of HCC in NOD/SCID mice.
Patient No. | Age/sex | Pathologic diagnosis | Edmonson grade | Hilar lymph node metastasis | Treatment | Success in s.c. transplantation | Spontaneous regression | Success in establishment of cell line |
---|---|---|---|---|---|---|---|---|
5 | 65/male | HCC | II | yes | hepatectomy | yes | no | yes |
8 | 36/male | Mixed HCC | II | no | hepatectomy | yes | no | no |
9 | 41/female | HCC | II | no | hepatectomy | yes | no | no |
10 | 56/male | HCC | II | yes | hepatectomy | yes | no | yes |
19 | 32/female | HCC | II | no | liver transplantation | yes | yes | no |
HCC, hepatocellular carcinoma; NOD/SCID, non-obese diabetic/severe combined immunodeficiency; s.c. transplantation: subcutaneous transplantation