Skip to main content
. 2013 Jun 10;110(26):10759–10764. doi: 10.1073/pnas.1308195110

Fig. 1.

Fig. 1.

Genetic elimination of both MC4R and SAPAP3 normalizes excessive grooming observed in singly deficient SAPAP3-null mice. (A) SAPAP3-null mice showed increased grooming time and number of grooming bouts at baseline (NS = “no spray”) and after grooming stimulus (S = “spray”) in the 5-min grooming assay, compared with wild-type and MC4R-null mice. (B) SAPAP3-null mice showed increased grooming time and number of grooming bouts relative to wild-type and MC4R-null mice in the 24-h home cage basal grooming assay. Time spent grooming and number of grooming bouts was normalized in double null mice in all aspects of 5-min and 24-h assays (data presented as mean ± SEM). (C) Double deletion of MC4R and SAPAP3 prevent acquisition of self-induced facial lesions, which are characteristic of SAPAP3-null mice.