Fig. 3.

MC4R deletion rescues ventral striatal synaptic transmission deficits in SAPAP3-null mice. (A) Representative traces of field potential recordings at 10-, 30-, and 50-µA stimulus intensities in wild-type, SAPAP3-null, MC4R-null, and double null ventral striatum (N1 first negative peak representing axonal stimulation, N2 second negative peak representing AMPAR antagonist sensitive potential). (B) Current-voltage relationship plot of ventral striatal N2 field potentials show reduced SAPAP3-null responses are rescued in double null acute slices. (C) Paired-pulse ratios at 50-ms interstimulus intervals are increased in SAPAP3-null mice and rescued in double null mice.