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Comparison of active (Left) and Src-like inactive (Right) structures of EGFR CD. Key structural elements are colored in red (αC helix), green (P-loop) and yellow (A-loop). Also shown as sticks is the DFG motif and the residues either mutated (L858, T790) or participating in salt-bridge interactions and used to define a collective variable (K745, D855, E762).
