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5-Cl-dC was analyzed in human colon tissue derived from patients with IBD and compared with previously determined levels in mice (UC, n = 18; CD, n = 22, Rag2−/− H. hepaticus-infected mice, n = 12) (11). The 5-Cl-dC levels in Rag2−/− H. hepaticus-infected mice were significantly higher than those observed in IBD colon tissues (P < 0.0002). Statistical significance between groups was assessed by the Mann–Whitney U test and the line represents the mean value in each dataset.
