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. 2013 Jun 12;110(26):10765–10770. doi: 10.1073/pnas.1301693110

Fig. 3.

Fig. 3.

Inactivation of miR-17∼92 in renal tubules of Kif3a-KO mice inhibits cyst growth. (A) H&E staining of kidneys from three different 28-d-old Kif3a-miR-17∼92-KO mice (Right) and Kif3a-KO mice (Left) is shown. Quantification revealed that kidney weight-to-body weight ratio (B), cyst index (C), and average cyst size (D) were reduced in Kif3a-miR-17∼92-KO mice (green) compared with Kif3a-KO mice (red). (E) No difference in cyst number was observed between the two groups. (F) Serum creatinine levels show improved renal function in 28-d-old Kif3a-KO mice compared with Kif3a-miR-17∼92-KO mice. (G) Kaplan–Meier survival curves of Kif3a-KO mice and Kif3a-miR-17∼92-KO. Median survival of Kif3a-KO mice was 104 d, and median survival of Kif3a-miR-17∼92-KO mice was 140 d. Error bars represent SEM.