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. 2013 Jun 10;110(26):E2420–E2427. doi: 10.1073/pnas.1309354110

Fig. 1.

Fig. 1.

CaMKKβ is required for SIRT1 induction in ECs under PS. (A–C) Immunoblots of HUVECs subjected to PS for the indicated time periods (A), pretreated with STO-609 (2.5 μg/mL) or DMSO for 30 min and then subjected to PS for 8 h (B), and transfected with control siRNA or CaMKKβ siRNA and then exposed to PS for 8 h or kept under static conditions for the same time (C). (D) Immunoblots of CaMKKβ+/+ and CaMKKβ−/− MEFs exposed to static condition or PS for 8 h. The antibodies against targeted proteins are indicated for each immunoblot. Bar graphs below immunoblots summarize the means ± SEM of three independent experiments. *P < 0.05.