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CaMKKβ and SIRT1 ablation enhances atherogenesis in mouse aorta. Macrophotographs of oil red O-stained aorta from CaMKKβ+/+ApoE−/− and CaMKKβ−/−ApoE−/− mice (A) and EC-SIRT1+/+/ApoE−/− and EC-SIRT1−/−/ApoE−/− mice (C) fed a Paigen diet for 9 wk and killed. (Scale bar: 0.5 cm.) (B and D) Quantification of percentage of lesion areas in the whole aorta (Left) and aortic arch (AA) and thoracic aorta (TA) (Right). *P < 0.05; n denotes the number of animals used.
