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. 2013 May 31;110(26):E2400–E2409. doi: 10.1073/pnas.1304308110

Fig. 2.

Fig. 2.

LTP is suppressed at the mPP-DG synapses in SR−/− mice. (A) Averaged fEPSPs (10 traces) evoked at the mPP-DG synapses by presynaptic stimuli of increasing intensity in slices from WT (Left) and SR−/− mice (Right). (B) Synaptic input-output curves obtained in slices from six WT (n = 10 slices) and five SR−/− (n = 11 slices) mice. (C) Examples of fEPSPs at the mPP-DG synapses evoked with paired stimuli (interstimulus intervals 50-ms) in slices from WT (Left) and SR−/− mice (Right). (D) Averaged paired-pulse ratio values in slices from five WT (n = 11 slices) and five SR−/− (n = 18 slices) mice at interstimulus intervals 50, 150, and 300 ms. Paired-pulse ratio was calculated as the ratio of the rising slope of the second fEPSP to the first fEPSP. (E and F) Summary of LTP experiments from five WT mice (n = 8 slices) and four SR−/− mice (n = 8 slices). LTP was induced by a 1-s train of 100 Hz stimulation. Insets in E and F are the averages of: 1, 40 fEPSPs recorded before; 2, 20 fEPSPs recorded 40 min after the induction (at arrow) of LTP in slices from WT and SR−/− mice. Asterisk (*) indicates significant difference from the WT group (P < 0.05). All values represent the mean ± SEM.