Table 1.

MEK and ERK signaling is unaltered in the hippocampus of SR^−/− mice

WT or SR	MEK		p-MEK		ERK-42		p-ERK-42		ERK-44		p-ERK-44
	% WT	P	% WT	P	% WT	P	% WT	P	% WT	P	% WT	P
WT	100 ± 5	0.9	100 ± 12	0.4	100 ± 4	0.5	100 ± 8	0.7	100 ± 8	0.5	100 ± 15	0.8
SR −/−	101 ± 6		88 ± 9		97 ± 4		95 ± 6		94 ± 7		92 ± 19

Protein levels of MAP kinase kinase (MEK-1/2), p-MEK (Ser218/Ser222), p44/42 MAPK (ERK-1/2), and phospho-ERK-1/2 (pERK; Thr202/Tyr204) were measured in the total hippocampal homogenate from WT (n = 6) and SR^−/− (n = 6) mice. Values are expressed as the optical density (OD) normalized to WT values (% WT). All values represent the mean ± SEM.