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. 2013 Jul 1;3:2101. doi: 10.1038/srep02101

Figure 2. Genomic features of S. cellulosum So0157-2.

Figure 2

(a) The genomic organization of the Sorangium cellulosum So0157-2 strain. Circle 1, genome positions in kb (from dnaA); Circles 2 and 4, predicted protein coding sequences (CDSs) on the forward (outer wheel) and the reverse (inner wheel) strands, colored according to COG class (leading strand, 5,825 CDSs, 49.9% of the total CDSs; lagging strand, 5,848 CDSs, 50.1% of the total CDSs); Circle 3, GC skew; Circles 5 and 6, putative ICE (integrative conjugative element)-derived CDSs (leading strand, 456 CDSs; lagging strand, 485 CDSs, 8.06% of the total CDSs); Circles 7 and 8, putative plasmid-derived CDSs (leading strand, 2,434 CDSs; lagging strand, 2,355 CDSs, 41% of the total CDSs); Circle 9, GC content showing deviations from the average (72.1%); Circles 10 and 11, putative HGT (horizontal gene transfer)-related genes (leading strand, 630 CDSs; lagging strand, 613 CDSs, 9.86% of the total CDSs); Circle 12, CDSs with regions showing high identity to virus genes; Circle 13, CDSs with regions showing high identity to prophage genes; Circle 14, putative restriction and modification system genes; Circle 15, two-component system genes in the genome (leading strand, cyan; lagging strand, purple); Circle 16, 109 sigma factor genes and 347 related transcription factors in the genome (leading strand, yellow; lagging strand, green); Circle 17, 55 CDSs with DNA-binding regions (green); Circle 18, secondary metabolite biosynthesis genes (dark purple), 10.6% of the whole genome; Innermost circle, putative paralogous genes in the genome. (b) Syntenic map between S. cellulosum So0157-2 and So ce56. (c) HGT (blue), ICE (red) and Plasmid, prophage and virus (green) are the three main mechanisms that have introduced alien genetic materials into the Sorangium genome. Generally, most ICEs fall into the green circle (932/941), whereas approximately 3/4 of the HGT genes lie in the green circle (908/1,268). A total of 197 genes are shared between the ICE and HGT groups. 193 genes are common to all three groups. About half of genes could be designated as alien genetic material (5,129/11,599).