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. 2013 Jun 25;2(6):e101. doi: 10.1038/mtna.2013.27

Figure 3.

Figure 3

Broad transduction of CD-1 mouse brain on P2 after E15 intracerebroventricular administration of rAAV9-GFP. (a) Representative images of GFP transgene expression in CD-1 mouse brains on P2 after rAAV9 injection on E15 shows robust expression of GFP (brown stain) in olfactory bulb, cerebral cortex, cerebellum, and brainstem. Bar, 100 μm. (b) Results of real-time PCR quantitation of rAAV9 genome copy number per mouse diploid genome in CD-1 mouse brain on P2 (n = 3). Consistent with the expression data in a, transduction appeared highest in olfactory bulb followed by brainstem, cortex, and cerebellum. Error bars represent SD corrected for log scale. GFP, green fluorescent protein; rAAV, recombinant adeno-associated virus.