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. 2013 Mar 15;30(6):441–452. doi: 10.1089/neu.2012.2622

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Copyright 2013, Mary Ann Liebert, Inc.

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FIG. 1. — Riluzole promotes locomotor recovery after SCI in rats. (A) Riluzole treatment 1 h post-injury (P1) provided the greatest improvements in BBB scores compared to vehicle-treated control group from second to sixth week post-injury (p=0.003). The group treated with riluzole 3 h post-SCI (P3) showed significant behavioral improvements compared to control group (p=0.014). (B) BBB subscore confirmed the neuroprotective effect of riluzole (P1) compared to vehicle-treated control (p=0.003). P3 group did not show significant improvements (p=0.141). (C) Gridwalk analysis revealed sensory-motor recovery in the P1 group from weeks 3 to 6 after injury with reduced number of footfalls (p=0.026), while the P3 group had a trend toward a decrease in the number of footfalls that did not reach significance (p=0.098). (D) Mechanical allodynia did not increase in response to treatment. Data are expressed as mean±SEM. *p<0.05, **p<0.01.