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. 2013 Mar 15;30(6):441–452. doi: 10.1089/neu.2012.2622

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Copyright 2013, Mary Ann Liebert, Inc.

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FIG. 6. — Immunofluorescence staining of perilesional macrophage/microglia. Diffuse infiltration of Iba1-positive cells was observed at 600 μm caudal to the injury epicenter. A significant decrease was found in Iba1-positive macrophages and microglia at 1 week after SCI in rats that received riluzole 1 h post-SCI (A) compared to control (B). Bar graph illustrating quantitative analysis of the integrated density of Iba1-positive cells in the spinal cord at 1 week (C) and 6 weeks (D) after SCI. There was a significant decrease in Iba1 density in P1 (p=0.033) and P3 (p=0.05) animals compared to controls at 6 weeks post-SCI. At 1 week post-SCI, the decrease in Iba1 density was significant in P1 rats (p=0.008) and P3 (p=0.041). Bar=500 μm.