FIG. 7.

Riluzole administration reduced apoptosis following SCI. Panels (A) and (B) are representative sections taken 700 μm caudal to the epicenter from a riluzole treated (P1) and control animal, respectively. Sections were immunostained with TUNEL (red) and counterstained at 7 days after SCI. Quantitative analysis revealed a significant decrease in TUNEL-positive cells in the riluzole treatment group (P1) versus control group (p=0.024) as shown in bar graph (C). Riluzole treatment at 3 h post-injury (P3) did not show significant reduction in apoptosis (p=0.492). A portion of apoptotic cells in the white matter was co-localized with CC1 labeled oligodendrocytes (D–G).