Figure 8.
The alpha-1 agonist phenylephrine exhibits no significant effect in P-P synapses. A and B, Phenylephrine (25 μM) exhibited no significant effect on a P-P pair. C, Cumulative probability of the first AMPA EPSC amplitudes showed overlapped curves (n = 8). D, Effects of phenylephrine on the first EPSC amplitude were unaltered (P = 0.883). E, The CVs of the first EPSC amplitudes were not significant (P = 0.928). F, G, and H, Binned first EPSC amplitudes in P-P pairs in baseline, phenylephrine, and wash, fitted with Gaussian function. The failure rates were slightly increased but not significant in phenylephrine (P = 0.431) and continuously unaltered in wash (P > 0.05).