Table 1.
NE effects on the properties of both pre- and post-synaptic neurons
P-FS (n=7) | FS-P (n=7) | P-P (n=12) | |||||||
---|---|---|---|---|---|---|---|---|---|
Pre-NE | Post-NE | P value | Pre-NE | Post-NE | P value | Pre-NE | Post-NE | P value | |
Presynaptic Neuron | |||||||||
Resting membrane potential (mV) | −67.9±2.04 | −66.0±2.10 | 0.131 | −70.0±1.74 | −66.0±1.80 | 0.222 | −65.7±5.10 | −66.1±6.92 | 0.878 |
input resistance (MΩ) | 112±16.3 | 118±22.3 | 0.572 | 200±31.6 | 211±38.8 | 0.50 | 135±48.9 | 137±38.8 | 0.820 |
Membrane time constant (ms) | 29.5±3.15 | 28.0±3.26 | 0.640 | 7.55±1.36 | 8.70±1.99 | 0.221 | 26.5±1.33 | 25.0±1.55 | 0.303 |
AP threshold (mV) | −44.2±1.88 | −3.7±1.32 | 0.811 | −5.2±1.12 | −3.4±1.33 | 0.255 | −2.6±1.23 | −1.2±0.85 | 0.374 |
AP half-width (ms) | 1.79±0.17 | 2.04±0.21 | 0.122 | 0.46±0.12 | 0.47±0.12 | 0.136 | 2.24±0.25 | 2.35±0.23 | 0.697 |
Postsynaptic neuron | |||||||||
inject current (pA) | −17.5±16.2 | −35.4±14.6 | 0.147 | 20.6±14.9 | −2.8± 15.6 | 0.084 | −6.17±12.1 | −2.99±11.4 | 0.605 |
Latency (ms) | 0.52±0.10 | 0.58±0.06 | 0.331 | 0.50±0.06 | 0.48±0.06 | 0.278 | 0.99±0.10 | 0.99±0.09 | 0.918 |
Amplitude (pA) | 36.9±15.6 | 10.4±4.76 | 0.058 | 30.5±15.5 | 25.0±13.4 | 0.140 | 11.5±2.06 | 11.0±3.02 | 0.861 |
20–80% rise time (ms) | 0.71±0.09 | 0.93±0.19 | 0.272 | 0.68±0.07 | 0.96±0.16 | 0.123 | 1.41±0.29 | 1.32±0.17 | 0.577 |
63% decay time (ms) | 5.50±0.94 | 5.90±1.19 | 0.7196 | 8.23±0.85 | 10.2±1.55 | 0.0967 | 11.2±1.79 | 9.50±1.55 | 0.2649 |
Half-duration (ms) | 5.81±1.10 | 5.88±0.87 | 0.9304 | 12.7±1.18 | 12.8±1.33 | 0.9411 | 10.8±1.80 | 10.7±1.72 | 0.8806 |