Table 2.

The training dataset (this work) of miRNA affinities for the human Ago2 and Ago3 proteins (Azuma-Mukai et al., 2008); 12 miRNA fragments each 22 nt in length are in CAPITALS.

Experimental data in vivo (Azuma-Mukai et al., 2008)				Analysis in silico (this work)
miRNA	Canonical miRNA sequence	[miR/Ago2] ln-un., X2	[miR/Ago3] ln-un., X3	Δ, (X2−X3)/2	[RHHK]F3	Σ, (X2+X3)/2	[YRHB]F4
hsa-mir-342	uCUCACACAGAAAUCGCACCCGU	7.81	4.85	1.48	1.95	6.33	0.77
hsa-mir-21	UAGCUUAUCAGACUGAUGUUGA	8.34	7.24	0.55	1.59	7.79	1.45
hsa-mir-378	ACUGGACUUGGAGUCAGAAGGC	4.97	5.89	−0.46	1.26	5.43	0.00
hsa-mir-629	GUUCUCCCAACGUAAGCCCAGC	5.28	7.98	−1.35	0.91	6.63	0.37
hsa-mir-92b	UAUUGCACUCGUCCCGGCCUCC	6.48	8.98	−1.25	0.22	7.73	1.06
hsa-mir-221	AGCUACAUUGUCUGCUGGGUUU	6.08	5.26	0.41	2.37	5.67	0.50
hsa-mir-29c	UAGCACCAUUUGAAAUCGGUUA	6.08	6.05	0.02	1.36	6.06	0.42
hsa-mir-210	CUGUGCGUGUGACAGCGGCUGA	6.81	7.96	−0.57	0.59	7.38	1.32
hsa-mir-let7d	CUAUACGACCUGCUGCCUUUCU	6.49	6.46	0.01	1.53	6.47	1.00
hsa-mir-99b	CACCCGUAGAACCGACCUUGCG	8.55	6.70	0.92	1.43	7.62	2.09
hsa-mir-191	CAACGGAAUCCCAAAAGCAGCU	6.40	7.47	−0.53	1.05	6.94	0.82
hsa-mir-425	aAUGACACGAUCACUCCCGUUGA	7.33	8.50	−0.59	0.10	7.92	1.99
Coefficient of linear correlation				r = 0.75		r = 0.86
Statistical significance				α < 0.005		α < 0.001