Figure 3. Increase in IFNγ response and decrease in IL-10 and IL-17 response to HCVantigens in the index patient approximately 2 years after spontaneous clearance (4 years post-OLT) compared to at the time of viral clearance (2.25 years post OLT).
ELISpot comparing IFNγ (Fig 3A), IL-10 (Fig 3B) and IL-17 (Fig 3C) responses to HCV core and NS4 antigen among index patient at time of presumed viral clearance (2.25 years post OLT - white bars), and two years following that (4 years post-OLT, grey bars). Following the period of presumed viral clearance there was an increase in IFN-γ response to HCV antigens with a decrease in IL-17 and IL-10 responses. (Statistical comparisons not made due to insufficient data points)