Table 2.

Hemodynamic and forearm vascular responses to sildenafil and placebo

	Sildenafil				Placebo				P valuea
	Baseline	30 min	45 min	60 min	Baseline	30 min	45 min	60 min
MAP, mm Hg	93±3	92±3	91±3	89±3	93±3	95±4	96±3	96±4	0.001
HR, bpm	53±3	57±4	55±4	55±4	55±3	53±3	55±4	52±3	0.03
FVR, mm Hg • min • 100mL/mL	36±4	35±5	37±6	—	31±3	39±6	38±5	—	0.16
FBF, ml/min/100ml tissue	2.8±0.3	2.9±0.3	2.7±0.3	—	3.2±0.3	2.8±0.3	2.8±0.3	—	0.19

Abbreviations: bpm, beats per minute; FBF, forearm blood flow; FVR, forearm vascular resistance; HR, heart rate; MAP, mean arterial pressure.

^aAnalysis of variance: group × time interaction (group = sildenafil or placebo).