Table 4.
Results of Cox proportional hazards regression analyses predicting transition time from first drink to onset of first alcohol use disorder (AUD) symptoma
| Base model HR (95% CI) |
Model with Covariates HR (95% CI) |
|
|---|---|---|
| Cannabis use | 1.16 (0.96–1.40) | 1.18 (1.00–1.38) |
| Order of initiationb | ||
| Cannabis first | 0.69 (0.57–0.84)* | 0.68 (0.56–0.83)* |
| Same age | 0.79 (0.68–0.92)* | 0.78 (0.66–0.91)* |
| No cannabis | 0.40 (0.34–0.47)* | 0.45 (0.39–0.53)* |
| AA ethnicity | 0.72 (0.60–0.86)* | 0.74 (0.61–0.90)* |
| Maternal alcohol problems | 1.17 (1.00–1.36) | 1.03 (0.88–1.21) |
| Paternal alcohol problems | 1.23 (1.09–1.39)* | 1.09 (0.97–1.24) |
| Childhood physical abuse or neglect (CPAN) |
– | 1.09 (0.95–1.25) |
| Childhood sexual abuse (CSA) | – | 1.14 (0.97–1.33) |
| Major depressive disorder (MDD) | – | 1.38 (1.22–1.55)* |
| Conduct disorder (CD) | – | 1.47 (1.19–1.82)* |
| Regular smoking | – | 1.22 (1.04–1.44)* |
AA, African-American; HR, hazard ratio; CI, confidence interval.
Adjusted for age at time of symptom report, age at first use, sampling design, and proportional hazards violations.
Alcohol first as reference group.
p < 0.05.