Table 1.
The cytokine expression in Apligraf and human skin
| Human Keratinocytes | Human Dermal Fibroblasts | Apligraf | Human Skin | |
|---|---|---|---|---|
| FGF-1 | + | + | + | + |
| FGF-2 | − | + | + | + |
| FGF-7 | − | + | + | + |
| ECGF | − | + | + | + |
| IGF-1 | − | − | + | + |
| IGF-2 | − | + | + | + |
| PDGF-AB | + | + | + | + |
| TGF-α | + | − | + | + |
| IL-1α | + | − | + | + |
| IL-6 | − | + | + | + |
| IL-8 | − | − | + | + |
| IL-11 | − | + | + | + |
| TGF-β1 | − | + | + | + |
| TGF-β3 | − | + | + | + |
| VEGF | + | − | + | + |
FGF = fibroblast growth factor; ECGF = endothelial cell growth factor; IGF = insulin-like growth factor; PDGF = platelet-derived growth factor; TGF = transforming growth factor; IL = interleukin; VEGF = vascular endothelial growth factor.