Figure 1.

Fuz Mutant Mice Are a Model for High Arched Palate

(A and B) Ventral views of E17.5 palates. Mutants exhibit a narrow palate (arrowheads) and disrupted rugal organization compared to littermates.

(C and D) Sirius red/alcian blue staining of E17.5 coronal sections. Bilateral palatine bones are formed in both control and mutant, abutting at the midline (black). Mutant palatine bones (Pb) are mediolaterally shortened with an increase in the ventral extension. Note enlarged palatal mesenchyme (P). Molars (M) appear normal.

(C′ and D′) Schematics depicting skewed palatal anatomy.

(E–J) Hemotoxylin and eosin staining of coronal sections at indicated stages.

(E′–J′) Schematics of sections identifying palatal mesenchyme (gray, P), molars (blue and purple, M), and palatal bone condensations (red, Pb). In (H) through (J′), mutant palatal condensations are medially constrained and do not extend into the oral cavity. Palatine bone can be observed in both mutants and controls by E16.5.

See also Figure S1.