Figure 5.
Maxillary Hyperplasia Is Not Due to Fuz Function in the NC
(A and B) Lateral views of E17.5 Wnt1-cre; Fuzfl/+ and Wnt1-cre; Fuzfl/− embryos. The control embryo in (A) is an albino and lacks pigment in the eye. Arrowheads indicate rostral midline.
(A′ and B′) Frontal views of E17.5 Wnt1-cre; Fuzfl/+ and Wnt1-cre; Fuzfl/− embryos. A cleft lip is observed in conditional null embryos [(B′) compared to (A′), indicated by arrowheads].
(A″ and B″) Hemotoxylin and eosin (H&E) staining of coronal sections of E17.5 Wnt1-cre; Fuzfl/+ and Wnt1-cre; Fuzfl/− embryos. Sections show the anterior secondary palate (P), tongue (T), and molars (M). Palatal shelves are elevated and fused across the midline in control embryos; however, a failure in shelf elevation is observed in Wnt1-cre; Fuzfl/− embryos [(B″) compared to (A″), indicated by P]. The tongue also appears smaller and irregularly shaped in mutants [(B″) compared to (A″) indicated by T].