TABLE 2.
Summary of Results from Rats Irradiated With 5, 10 or 13 Gy to The Thorax
| Whole thoracic irradiation (Gy) |
Weeks after irradiation |
Average no. of cholesterol cleft/ whole mount section |
Functional analysis (at the time of cholesterol cleft count) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Breathing rate | Body weight | Lung collagen | Total lung ACE activity |
Right ventricular hypertrophy |
Pulmonary vascular resistance |
Dry lung weight | Arterial distensibility |
|||
| 5 | 56 | 0 | N/Ad | ± (22) | N/A | ↓(22) | ± (22) | ± (22) | ± (22) | ± (22) |
| 10 | 53 | 14 | ±a (15) | ↓(c (22) | N/A | ↓(22) | ± (22) | ± (22) | ↑ (22) | ↓(22) |
| 13 | 30 | 19 | ↑b (10) | ↓( | ↑(10, 16) | ↓( | ↑ | ↑ | ↑ | ↓( |
a
No significant change.
b
Significantly increases compared with age-matched controls.
c
Significantly decreases compared with age-matched controls
d
Data not available.