Table 4.

Association Analysis of CYP2D6 Phenotype and CYP1A2 Genotype with Tardive Dyskinesia (TD) in Univariate Analysis and Logistic Regression (L-R)

Cohort	Test	CYP2D6			Univariate p-value	L-R test p-value (racexgene p-value)	CYP1A2*1F			Univariate p-value (smokers only)
		EM	IM	PM			HH	LH	LL
All	TD positive	113	24	5	0.15	0.66 (0.1)	65	60	16	0.55 (0.45)
	TD absent	441	59	27			259	228	45
Caucasian	TD positive	71	14	5	0.05	0.33	44	39	6	0.77 (0.41)
	TD absent	307	26	22			187	153	18
African American	TD positive	39	7	0	0.62	0.16	19	17	10	0.57 (0.74)
	TD absent	115	28	4			59	66	24

Pearson’s p-values are reported for the univariate analysis, accept for CYP2D6 association analysis in African-Americans, where Fisher’s exact test p-value is listed.

Abbreviations: EM, extensive metabolizer; IM, intermediate metabolizer; PM, poor metabolizer; H, higher inducibility allele; L, lower inducibility allele.