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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Genet Med. 2008 Oct;10(10):720–729. doi: 10.1097/GIM.0b013e3181863239

Table 5.

Antipsychotic Drugs Analyzed and the DMEs that Metabolize Them

Drug Major
DME		 Secondary
DME		 Minor
DME1		 Minor
DME2		 Minor
DME3		 Transporter Glucuronidase
1 Olanzapine CYP1A2 FMO3 CYP2D6 CYP3A4
&
CYP3A5		 UGT1A4
2 Quetiapine CYP3A4
&
CYP3A5		 CYP2D6 CYP2C9 ABCB1
3 Risperidone CYP2D6 CYP3A4
&
CYP3A5		 ABCB1
4 Ziprasidone AOX1* CYP3A4
&
CYP3A5		 ABCB1
5 Perphenazine CYP2D6 CYP1A2 CYP2C9 CYP2C19 CYP2C8

Abbreviations: DME, drug metabolizing enzyme; CYP, cytochrome P450; AOX1, aldehyde oxidase 1; FMO3, flavin-containing monoxigenase 3; ABCB1, p-glycoprotein (MDR1); UGT1A4, uridine 5′-diphosphate glucuronosyl transferase 1A4.

*

There are no common functional variants in AOX1 and inhibitors and inducers of the enzyme do not affect ziprasidone pharmacokinetics44,4536, 37. AOX1 was thus not analyzed in this report.