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. 2013 Jun 13;2013:375263. doi: 10.1155/2013/375263

Table 2.

Management of FK toxicity and outcomes.

Patient number Hospital day of phenytoin initiation Phenytoin dose (mg/day)/duration (days) Other management Days to FK <15 ng/mL Days to resuming tacrolimus Days to baseline SCr Outcome/followup (months)
1 1 400/3 HAART temporarily withheld 2 5 Alive, stable renal function/60
2 1 400/2 Fluconazole temporarily withheld 3 5 10 Died, cardiac arrest/7
3 1 300/3 Herbal products stopped 3 4 10 Alive, stable renal function/13
4 2 400/3 Voriconazole stopped 3 4 3 Alive, stable renal function/8

*Patient baseline creatinine 1.7 mg/dL did not return back to baseline but settled with creatinine of 2.2 mg/dL.