. Author manuscript; available in PMC: 2013 Jul 1.

Published in final edited form as: J Nat Prod. 2009 Aug;72(8):1524–1528. doi: 10.1021/np900177m

Table 2.

Fractional Inhibitory Concentrations (FICs)^a of Combination Treatment FLU with 1, 2, and Beauvericin

	S. cerevisiae Null pump^b	S. cerevisiae CDR1^b	S. cerevisiae MDR1^b	C. albicans #1^b,^c	C. albicans #17^b,^d	C. albicans 1587^e,^f	C. albicans 1758^e,^g
1	1.10	1.04	0.08	1.5	1.3	1.7	0.2
2	0.75	1.34	0.15	1.7	1.8	1.6	0.2
beauvericin	3.38	0.04	2.28	0.5	0.7	0.5	2.8

FIC [(IC₅₀ of test compound in combination with FLU/IC₅₀ of test compound alone) + (IC₅₀ of FLU in combination with test compound/IC₅₀ of FLU alone)] ≤ 0.5 = synergistic; 0.51–1.0 = additive; 1.1–2.0 = indifferent; > 2.0 = antagonistic.

Concentration of 1 = 13 µM, 2 = 13 µM, beauvericin = 26 µM.

FLU-susceptible isolate.

FLU-resistant isolate (multiple resistant mechanisms).

Concentration of 1 = 189 µM, 2 = 194 µM, beauvericin = 5.7 µM.

FLU-susceptible isolate.

FLU-resistant isolate overexpressing MDR1 efflux pump.