Table 1.

Effect of C4 against promastigote and axenic amastigote forms of Leishmania amazonensis, cytotoxicity in macrophages cells, and selectivity index.

Cells	C4 (µM) IC50 a	C4 (µM) IC90 b	SIc
Promastigotes	16.0 ± 2.28	103.0 ± 20.17	45.1
Axenic amastigotes	16.3 ± 2.38	118.0 ± 45	44.2
Macrophages (CC50)d	722.0 ± 45	—	—

^aConcentration that inhibited 50% of growth.

^bConcentration that inhibited 90% of growth.

^cSelectivity index (SI; CC₅₀ macrophages/IC₅₀).

^d50% cytotoxicity concentration in macrophages.