Table 4.
Allelic polymorphisms observed in MRR1 and ERG11 for C. albicans strains
Gene and isolate | Allele (GenBank accession no.) | Amino acid substitution(s)a |
---|---|---|
MRR1 | ||
DSY291 | Allele 1 (EU497754) | – |
Allele 2 (EU497755) | S16I, T73K, S171P, E1020Q, 2× NPQS | |
JEY355 | Allele MRR1V877F (KC676659) | S16I, T73K, S171P, V877F, E1020Q, 2× NPQS |
JEY429 | Allele MRR1V877F | S16I, T73K, S171P, V877F, E1020Q, 2× NPQS |
JEY430 | One allele 2 from DSY291 | S16I, T73K, S171P, E1020Q, 2× NPQS |
JEY431 | Two MRR1V877F alleles | S16I, T73K, S171P, V877F, E1020Q, 2× NPQS |
JEY432 | Two alleles 2 from DSY291 | S16I, T73K, S171P, E1020Q, 2× NPQS |
ERG11 | ||
JEY355 | Allele 1 (KC676660) | E266D |
Allele 2 (KC676661) | D116E, E266D |
–, Only amino acids that differ from those of Mrr1 of strain SC5314 are listed. The new gain-of-function mutation is indicated in boldface.