Table 2.
Characteristics of ESBL bacteremia episodes
| Variabled | Value for group |
P valuea | ||
|---|---|---|---|---|
| All patients (n = 232) | Therapy within 24 h that was deemed: |
|||
| Appropriate (n = 85; 37%) | Inappropriate (n = 147; 63%) | |||
| No. (%) of patients with origin of bacteremia | 0.14 | |||
| Community onset | 38 (16) | 10 (12) | 28 (19) | |
| Health care associated | 54 (23) | 25 (29) | 29 (20) | |
| Nosocomialb | 140 (60) | 50 (59) | 90 (61) | 0.53 |
| On medical ward | 58 (42) | 24 (48) | 34 (39) | |
| On surgical ward | 45 (33) | 14 (28) | 31 (35) | |
| On ICU | 35 (25) | 14 (24) | 21 (26) | |
| No. (%) of patients with definitive bacteremia sourcec | 0.03 | |||
| Primary or unknown | 24 (10) | 7 (8) | 17 (12) | |
| Urinary tract infection | 97 (42) | 38 (45) | 59 (40) | |
| Pneumonia | 11 (5) | 0 (0) | 11 (7) | |
| Vascular catheter infection | 20 (9) | 9 (11) | 11 (7) | |
| Intra-abdominal infection | 64 (28) | 22 (26) | 42 (29) | |
| Surgical wound infection | 5 (2) | 3 (4) | 2 (1) | |
| Skin/soft tissue infection | 6 (3) | 2 (2) | 4 (3) | |
| Other | 5 (2) | 4 (5) | 1 (1) | |
| No. (%) of patients with species isolated | 0.27 | |||
| E. coli | 163 (70) | 65 (76) | 98 (67) | |
| K. pneumonia | 44 (19) | 12 (14) | 32 (22) | |
| E. cloacae | 25 (11) | 8 (9) | 17 (12) | |
| No. (%) of patients with polymicrobial bacteremia | 22 (9) | 8 (9) | 14 (10) | 1.00 |
| No. (%) of patients with severe sepsis/septic shock (n = 226) | 75 (33) | 31 (37) | 44 (31) | 0.38 |
| No. (%) of patients with Pitt score of: | ||||
| ≥3 | 81 (35) | 29 (34) | 52 (35) | 0.88 |
| Unknown | 42 (18) | 19 (22) | 23 (16) | |
| No. (%) of patients with outcome | ||||
| ICU admission | 0.47 | |||
| No ICU admission | 168 (72) | 58 (68) | 110 (75) | |
| Already in ICU | 35 (15) | 13 (15) | 22 (15) | |
| Within 2 days after onset | 22 (9) | 10 (12) | 12 (8) | |
| Within 2–7 days after onset | 7 (3) | 4 (5) | 3 (2) | |
| In-hospital mortality (n = 230) | 54 (23) | 24 (28) | 30 (21) | 0.20 |
| Day 30 mortality (n = 231) | 46 (20) | 16 (19) | 30 (21) | 0.87 |
| Median (IQR) LOS after onset (days) | 15 (9–30) | 16 (10–34) | 14 (7–27) | 0.09 |
a
P value of comparison between patients with appropriate and those with inappropriate therapy, calculated with Pearson's chi-squared, Fisher's exact, or Mann-Whitney U test when applicable.
b
For two nosocomial cases, the ward type is unknown.
c
Divided into urinary tract infections, intra-abdominal infections, pneumonias, other sources, and unknown/primary sources for multivariable analysis for prediction of inappropriate therapy.
d
ICU, intensive care unit; IQR, interquartile range; LOS, length of stay.