Table 4.
Association of appropriateness of therapy within 24 h and possible confounders with day 30 mortalityc
| Variable | Mortality [no. of patients who died/total no. of patients (%)] | Unadjusted OR for mortality (95% CI) in univariable analysis | Association modela |
Adjusted OR for mortalityb (95% CI) in multivariable analysis | |
|---|---|---|---|---|---|
| Stratum-specific OR (95% CI) for appropriate therapy-mortality | MH pooled OR (95% CI) | ||||
| Appropriate therapy within <24 h | |||||
| Yes | 16/85 (19) | 1.12 (0.57–2.19) | 1.53 (0.68–3.45) | ||
| No | 30/146 (21) | ||||
| Charlson index | |||||
| <3 | 22/145 (15) | 2.16 (1.13–4.16)* | 1.15 (0.44–3.04) | 1.18 (0.59–2.34) | 2.80 (1.21–6.51)* |
| ≥3 | 24/86 (28) | 1.20 (0.46–3.17) | |||
| Patient age (yr) | |||||
| <75 | 29/177 (16) | 2.35 (1.17–4.72)* | 1.46 (0.61–3.53) | 1.21 (0.61–2.42) | 3.81 (1.55–9.39)* |
| ≥75 | 17/54 (31) | 0.86 (0.27–2.72) | |||
| LOS before onset (days) | |||||
| <21 | 33/169 (20) | 1.09 (0.53–2.25) | 0.79 (0.36–1.72) | 1.12 (0.57–2.19) | |
| ≥21 | 13/62 (21) | 2.95 (0.72–12.04) | |||
| Hospital ward at bacteremia onset | |||||
| Other | 31/196 (19) | 3.99 (1.85–8.64)* | 1.26 (0.56–2.86) | 1.13 (0.56–2.27) | 2.88 (1.05–7.85)* |
| ICU | 15/35 (43) | 0.81 (0.20–3.22) | |||
| Bacteremia source | |||||
| UTI | 8/96 (8) | 4.31 (1.91–9.71)* | 1.10 (0.25–4.90) | 1.05 (0.52–2.11) | 4.79 (1.74–13.16)* |
| Other | 38/135 (28) | 1.04 (0.47–2.29) | |||
| Bacteremia origin | |||||
| CO | 5/38 (13) | 1.78 (0.65–4.85) | 1.50 (0.15–15.28) | 1.16 (0.59–2.29) | |
| HC | 41/193 (21) | 1.13 (0.55–2.31) | |||
| Severe sepsis | |||||
| No | 14/150 (9) | 7.24 (3.53–14.71)* | 0.70 (0.23–2.15) | 1.34 (0.65–2.74) | 5.24 (2.36–11.60)* |
| Yes | 32/75 (43) | 2.10 (0.81–5.47) | |||
| Neutropenia | |||||
| No | 40/206 (19) | 1.31 (0.49–3.50) | 1.12 (0.54–2.33) | 1.15 (0.58–2.27) | |
| Yes | 6/25 (24) | 1.38 (0.22–8.67) | |||
a
Stratum-specific ORs to study confounding and effect modification of the association between appropriate therapy and mortality by the eight other variables.
b
Adjusted OR from forward stepwise logistic regression analysis, with appropriate therapy initially forced into the model (including 225 patients).
c
CO, community onset; HC, nosocomial or health care associated; ICU, intensive care unit; LOS, length of stay; MH, Mantel-Haenszel; UTI, urinary tract infection. *, P value of <0.05 determined by Pearson's chi-squared test or Wald test.