Concentration versus time profiles of ATV in liver (A), kidney (B), spleen (C), lung (D), brain (E), and site of injection (F) after multiple-dose administration of nanoART and native drug for 6 weeks. Doses were administered on days 0, 3, 7, 14, 21, 28, 35, and 42 at 50 mg/kg. Samples were collected right before dose administration on days 7, 14, 21, 28, 35, and 42 in mice (n = 6; data represent means ± SEM).