Table 3.
Tissue concentrations of ATV and RTV on day 14 after nanoART multiple-dose (day 0, 3, and 7) administration at 10, 50, 100 and 250 mg/kg in mice (n = 5)
| Drug and tissue | Concna (ng/g) at indicated dose |
|||
|---|---|---|---|---|
| 10 mg/kg | 50 mg/kg | 100 mg/kg | 250 mg/kg | |
| NanoART-ATV | ||||
| Liver | 39.7 ± 11.2 | 181.6 ± 19.3 | 1166.7 ± 355 | 6834.5 ± 2164 |
| Spleen | 6.7 ± 3.7 | 54.0 ± 24.0 | 4144.8 ± 672 | 6414.9 ± 3631 |
| Lung | 5.2 ± 1.3 | 18.1 ± 4.5 | 900.9 ± 787 | 215.5 ± 43 |
| Kidney | 5.8 ± 0.8 | 23.6 ± 4.1 | 138.7 ± 26.2 | 2867.0 ± 1575 |
| Brain | * | 2.2 ± 1.4 | 4.2 ± 0.9 | 17.2 ± 6.2 |
| NanoART-RTV | ||||
| Liver | 65.0 ± 8.5 | 331.9 ± 51.3 | 595.0 ± 106 | 2855.0 ± 754 |
| Spleen | 39.1 ± 4.4 | 169.0 ± 24.2 | 331.6 ± 32.1 | 651.3 ± 27.4 |
| Lung | 13.6 ± 2.5 | 59.6 ± 10.3 | 189.2 ± 54.6 | 243.2 ± 27.6 |
| Kidney | 52.1 ± 5.5 | 281.1 ± 39.3 | 487.9 ± 35.4 | 1366.0 ± 258.7 |
| Brain | * | 2.9 ± 0.3 | 6.9 ± 1.2 | 12.3 ± 1.3 |
a
Data represent means ± SEM. *, value is below the LLOQ.