Fig 3.

Cross-resistance. The resistant parasite populations or clones (i.e., C1, C2, and C3) were tested for susceptibility to other compounds to assess cross-resistance. The heights of the bars indicate the resistant IC₅₀/wild-type IC₅₀ (R/WT) ratios. The averages of the resistant/wild-type ratios of the clones were compared for statistical significance by unpaired t tests. (A) The bars for 1433 and 1312 are significantly higher (P < 0.0001) than the bars for eflornithine and pentamidine. (B) Again, the bars for 1433 and 1312 are significantly higher (P < 0.005) than the bars for eflornithine or pentamidine. The inset displays the data on a smaller y axis (0 to 8 instead of 0 to 200). (C) The pentamidine bars are significantly higher (P < 0.0001) than the bars for 1433, 1312, and eflornithine. (D) The bars for eflornithine are significantly higher (P < 0.002) than the bars for 1433, 1312, and pentamidine.