Fig 4.

In vitro growth rates of resistant T. brucei. The asterisks indicate 1.9 μM compound 1433 was present. The growth of wild-type clones in the absence of drug (♢ and △) was significantly greater (P < 0.0025) than the growth of 1433-resistant clones in the absence (● and ◆) or presence (▼ and ■) of 1433 at 24, 48, and 72 h. The growth of wild-type clones in the presence of 1433 (○ and □) was significantly less (P < 0.001) than the growth of the other clones at 24, 48, and 72 h. The error bars indicate the standard errors of the mean.