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A mutation at position 591 within the SPAM domain of Pfmspdbl2 is associated with parasite responses to halofantrine (A), mefloquine (B), and lumefantrine (C) in 45 Senegalese parasites. SNP calls and drug data are from reference 13; horizontal lines show the mean IC50s of the groups. P = 0.021 for halofantrine, P = 0.016 for mefloquine, and P = 0.014 for lumefantrine (two-tailed unpaired t tests of S591 versus C591).
