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. 2013 Jul;57(7):3131–3136. doi: 10.1128/AAC.00451-13

Fig 3.

Fig 3

Oral activity of MAL5166 in vivo. Doxycycline (DOX) and MAL5166 (5166) were tested in an early-stage P. berghei model of murine malaria. Compounds were given at the indicated dose by oral administration for 4 days after infection (n = 5/group). Animals were sacrificed at 15 days after infection; thus, data on long-term survival are not available. (A) Survival curves are presented as percent survival/group. The arrow denotes the end of treatment. (B) The PD50 (50% protective dose) on days 10 and 15 postinfection (pi) were calculated as an early endpoint evaluation of efficacy. CI, confidence interval.