Table 1.
Comparison of BioPlex 2200 Syphilis IgG, ARCHITECT Syphilis TP, and TPHA to IgG WB assay
| Assay and result | IgG WB result (no. of samples) |
% sensitivity (95% CI) | % specificity (95% CI) | % agreement (95% CI) | κ value | |
|---|---|---|---|---|---|---|
| Positive | Negative | |||||
| BioPlex 2200 Syphilis IgG | ||||||
| Positive | 352 | 48 | 100 (99–100) | 89.7 (86.6–92.3) | 94.2 (92.5–95.8) | 0.88 |
| Negative | 0 | 420 | ||||
| ARCHITECT Syphilis TP | ||||||
| Positive | 352 | 101 | 100 (99–100) | 78.4 (74.4–82.1) | 87.7 (85.4–89.9) | 0.76 |
| Negative | 0 | 367 | ||||
| TPHA | ||||||
| Positive | 351 | 1 | 99.7 (98.5–99.9) | 99.8 (98.8–100) | 99.8 (99.4–99.9) | 0.98 |
| Negative | 1 | 467 | ||||