Fig 5.

Effect of lipopolysaccharide (LPS) treatment on hepatic neutrophil infiltration in wild-type (WT) and TRPV1-null mutant (TRPV1^−/−) mice. (A) Immunohistochemically stained sections from the liver demonstrating neutrophils in the liver of control WT and TRPV1^−/− mice and WT and TRPV1^−/− mice treated with LPS. (B) Bar graph showing the number of hepatic neutrophils, expressed as cells per square millimeter. Tissue samples were harvested at 6 or 24 h after intraperitoneal injection of vehicle or LPS (5 million endotoxin units/kg). Values are means ± SE (n = 6 to 8). *, P value of <0.05 compared with control WT or TRPV1^−/− mice; †, P value of <0.05 compared with LPS-treated WT mice.