Fig 8.

Effect of lipopolysaccharide (LPS) treatment on renal ICAM-1 and VCAM-1 protein expression in wild-type (WT) and TRPV1-null mutant (TRPV1^−/−) mice. (A and C) Representative Western blots of ICAM-1 (A) and VCAM-1 (C) in the kidney of control WT and TRPV1^−/− mice and WT and TRPV1^−/− mice treated with and without LPS. (B and D) Bar graphs showing the relative optical density values for ICAM-1 (B) and VCAM-1 (D) in WT and TRPV1^−/− mice with and without LPS. Tissue samples were collected at 6 or 24 h after intraperitoneal injection of vehicle or LPS (5 million endotoxin units/kg). Protein expression levels are normalized with the housekeeping protein β-actin. Values are means ± SE (n = 4 to 5). *, P value of <0.05 compared with control WT or TRPV1^−/− mice; †, P value of <0.05 compared with LPS-treated WT mice.