Table 1.

Survival of NZW rabbits following lethal B. anthracis spore challenge and levofloxacin treatment with or without concomitant AVA vaccination (rabbit PEP study)

Group	Vaccine dose	Levofloxacin treatment	Spore challenge	Survival rate		Pa
				No. alive/total no.	%
1	Human dose	+	+	24/24	100	<0.0001
2	1:4	+	+	24/24	100	<0.0001
3	1:16	+	+	21/22b	95.5	<0.0001
4	1:64	+	+	16/23b	69.6	0.0038
5	Adjuvant	+	+	5/22b	22.7
6	None	−	+	0/12	0
7	1:4	+	−	23/23b	100
8	1:16	+	−	24/24	100

^aCompared to group 5.

^bTwo rabbits each in groups 3 and 5, and one rabbit each in groups 4 and 7, died during the oral gavage levofloxacin administration. The death of these animals was not related to anthrax infection (which was confirmed by histopathology for the challenged animals), and these animals were excluded from the statistical analyses.