Table 2.
ToxoDB Version 5 ID | Product | Fold induction | P value | TM (no.) | SP |
---|---|---|---|---|---|
Protein modification | |||||
TGME49_007070 | Glycosyl transferase | 4.10 | 0.007 | No | No |
TGME49_097720 | Glycosyl transferase domain | 6.84 | 0.044 | No | No |
Protein degradation | |||||
TGME49_017160 | Derlin-1 | 6.97 | 0.012 | 4 | Yes |
TGME49_095670 | E3 ubiquitin ligase | 2.80 | 0.010 | No | No |
TGME49_071490 | Endoprotease | 7.72 | 0.005 | 1 | Yes |
Quality control and protein folding | |||||
TGME49_063170 | Heat shock protein | 9.36 | 0.000 | No | No |
TGME49_077230 | Calruticulin | 3.44 | 0.002 | No | No |
TGME49_094870 | Universal stress protein/chaperone | 4.05 | 0.007 | No | No |
Vesicle transport | |||||
TGME49_073070 | GTPase activating protein for Arf domain-containing protein | 3.55 | 0.044 | No | Yes |
TGME49_014170 | Prenyltransferase | 4.14 | 0.041 | No | Yes |
Lipid and membrane metabolism | |||||
TGME49_063740 | ATP-binding cassette, lipid transporter | 5.31 | 0.005 | 5 | No |
TGME49_078110 | 1,3-Beta-glucan synthase | 4.34 | 0.038 | 11 | No |
TGME49_046010 | Esterase/lipase | 10.76 | 0.008 | No | No |
TGME49_050360 | Esterase/lipase | 1.42 | 0.043 | No | No |
Shown are Toxoplasma genes whose expression is induced by tunicamycin treatment. Like other eukaryotes, the Toxoplasma UPR contains factors involved in protein modification, folding, degradation, vesicle transport, and lipid/membrane metabolism. Statistical analysis was performed as described for Table 1. TMHMM and SignalP were used to predict the presence or absence of transmembrane (TM) domains and signal peptide (SP) sequences.