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. 2013 Jul;195(13):3073–3083. doi: 10.1128/JB.00121-13

Fig 7.

Fig 7

Effect of elrR inactivation on E. faecalis virulence. Kaplan-Meier survival analysis in a mouse peritonitis model with the OG1RF wild-type strain (open circles), the ΔelrA mutant strain (squares), the ΔelrR mutant strain (inverted triangles), the ΔelrR ΔelrA double mutant strain (diamonds), and the elrR-complemented strain (closed circles). Data were pooled from two independent experiments, except for the ΔelrR-complemented strain. A total of 20 mice were infected intraperitoneally with 1.4 × 109 or 0.85 × 109, 1.3 × 109 or 0.9 × 109, 1.5 × 109 or 1.1 × 109, and 1.3 × 109 or 0.98 × 109 CFU of OG1RF, ΔelrA, ΔelrR, and ΔelrR ΔelrA strains, respectively. A total of 10 mice were infected with 1.6 × 109 CFU of the ΔelrR-complemented strain. For each pairwise comparison, OG1RF/ΔelrR, ΔelrR/ΔelrR ΔelrA, and ΔelrA/ΔelrR ΔelrA, P values were <0.0001, <0.005, and <0.15, respectively.