Fig 7.

Immune response to whole-cell alga oral immunization in naive mice. Mice were administered weekly doses of JAG101 algae or ΔpsbA C. reinhardtii. Serum IgG antibodies for Pfs25 (A) and CtxB (B) were detected by ELISA. Error bars indicate standard errors of the means. Pfs25 (C)- and CtxB (D)-specific IgA antibodies in fecal extracts diluted to 0.5 mg/ml were detected by ELISA. Error bars indicate 1 standard deviation. Arrows indicate when oral doses were administered. ^, P < 0.05; ^^, P < 0.01.