Table 2.
HLA allelic associations with anthrax protective antigen-specific lymphoproliferative responses
| HLA locus | Allele | n | Median SI | Q1 | Q3 | Allele P value | Global P valuea |
|---|---|---|---|---|---|---|---|
| A | *6801 | 15 | 1.28 | 1.09 | 2.23 | 0.004 | 0.223 |
| B | *3503 | 8 | 1.43 | 1.16 | 3.33 | 0.029 | 0.553 |
| *4403 | 39 | 2.58 | 1.45 | 7.36 | 0.046 | ||
| C | *0102 | 16 | 7.01 | 1.80 | 13.21 | 0.005 | 0.206 |
| DPA1 | None | 0.809 | |||||
| DPB1 | *0201 | 81 | 2.71 | 1.34 | 7.11 | 0.085 | 0.258 |
| *1001 | 9 | 4.53 | 2.33 | 10.04 | 0.063 | ||
| *1501 | 5 | 8.49 | 1.66 | 17.08 | 0.024 | ||
| DQA1 | None | 0.565 | |||||
| DQB1 | *0502 | 10 | 4.15 | 2.02 | 8.59 | 0.047 | 0.058 |
| *0604 | 19 | 5.03 | 1.42 | 11.94 | 0.011 | ||
| DRB1 | *0102 | 21 | 1.80 | 1.31 | 2.58 | 0.092 | 0.133 |
| *0407 | 6 | 0.89 | 0.62 | 1.25 | 0.059 | ||
| *1101 | 39 | 4.05 | 1.46 | 7.84 | 0.009 | ||
| *1363 | 5 | 17.08 | 1.42 | 26.09 | 0.086 |
a
Data represent the results of linear regression analysis. P values for SI levels were determined on the basis of log transformation. Analyses were adjusted for gender, age groups, study site, route of immunization, time between vaccinations, time between blood draw procedures, and number of AVA doses. Alleles corresponding to P < 0.10 are included.