Table 3.
HLA homozygosity associations with lymphocyte proliferation to anthrax protective antigen
| HLA locus parameter | Category or level | n | Median SI | Q1 | Q3 | P valuea |
|---|---|---|---|---|---|---|
| 4 digit | ||||||
| A | Heterozygous | 231 | 2.13 | 1.24 | 6.78 | 0.005 |
| Homozygous | 44 | 1.48 | 1.03 | 2.28 | ||
| B | Heterozygous | 258 | 2.08 | 1.24 | 6.40 | 0.105 |
| Homozygous | 17 | 1.17 | 0.98 | 1.65 | ||
| C | Heterozygous | 250 | 2.08 | 1.24 | 6.40 | 0.067 |
| Homozygous | 25 | 1.51 | 1.07 | 2.28 | ||
| DRB1 | Heterozygous | 249 | 1.94 | 1.22 | 6.23 | 0.295 |
| Homozygous | 26 | 1.84 | 1.03 | 4.53 | ||
| DPA1 | Heterozygous | 102 | 2.03 | 1.17 | 7.38 | 0.342 |
| Homozygous | 173 | 1.90 | 1.19 | 4.80 | ||
| DQA1 | Heterozygous | 225 | 2.11 | 1.25 | 6.78 | 0.007 |
| Homozygous | 50 | 1.75 | 1.04 | 2.64 | ||
| DQB1 | Heterozygous | 233 | 2.13 | 1.25 | 6.92 | 0.002 |
| Homozygous | 42 | 1.48 | 1.01 | 2.23 | ||
| DPB1 | Heterozygous | 213 | 2.11 | 1.21 | 6.76 | 0.097 |
| Homozygous | 62 | 1.62 | 1.12 | 3.78 | ||
| Any locus | Heterozygous | 70 | 2.95 | 1.30 | 9.56 | 0.009 |
| Homozygous | 205 | 1.84 | 1.16 | 4.49 | ||
| No. homozygous | 0 | 70 | 2.95 | 1.30 | 9.56 | <0.001 |
| 1 | 81 | 1.89 | 1.22 | 5.05 | ||
| 2 | 69 | 2.13 | 1.25 | 6.40 | ||
| 3 | 27 | 1.69 | 1.02 | 3.62 | ||
| 4+ | 28 | 1.40 | 1.02 | 2.08 | ||
| 2 digit | ||||||
| A | Heterozygous | 230 | 2.13 | 1.24 | 6.78 | 0.006 |
| Homozygous | 45 | 1.51 | 1.04 | 2.33 | ||
| B | Heterozygous | 253 | 2.11 | 1.25 | 6.68 | 0.017 |
| Homozygous | 22 | 1.20 | 0.96 | 1.65 | ||
| C | Heterozygous | 237 | 2.02 | 1.22 | 6.28 | 0.343 |
| Homozygous | 38 | 1.67 | 1.14 | 4.69 | ||
| DRB1 | Heterozygous | 232 | 2.11 | 1.25 | 6.74 | 0.020 |
| Homozygous | 43 | 1.57 | 1.04 | 2.64 | ||
| DPA1 | Heterozygous | 90 | 1.86 | 1.13 | 6.92 | 0.669 |
| Homozygous | 185 | 1.94 | 1.22 | 5.05 | ||
| DQA1 | Heterozygous | 188 | 2.29 | 1.27 | 7.20 | 0.017 |
| Homozygous | 87 | 1.78 | 1.06 | 3.62 | ||
| DPB1 | Heterozygous | 187 | 2.12 | 1.22 | 7.29 | 0.059 |
| Homozygous | 88 | 1.69 | 1.11 | 3.60 | ||
| DQB1 | Heterozygous | 184 | 1.97 | 1.24 | 5.89 | 0.456 |
| Homozygous | 91 | 1.86 | 1.12 | 6.06 | ||
| Any locus | Heterozygous | 44 | 2.34 | 1.15 | 6.73 | 0.901 |
| Homozygous | 231 | 1.90 | 1.19 | 5.87 | ||
| No. homozygous | 0 | 44 | 2.34 | 1.15 | 6.73 | 0.006 |
| 1 | 57 | 3.10 | 1.28 | 11.23 | ||
| 2 | 80 | 2.03 | 1.38 | 4.53 | ||
| 3 | 40 | 1.89 | 1.25 | 7.07 | ||
| 4+ | 54 | 1.38 | 1.02 | 2.36 |
a
P values for SI levels were determined on the basis of log transformation. Statistically significant P values are in bold type (P < 0.05). IQR, interquartile range. Linear regression analysis was adjusted for gender, age groups, study site, route of immunization, time between vaccinations, time between blood draw procedures, and number of AVA doses.