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Hmox1-deficient mice have increased cell death. (A and B) Cell death in the livers of BALB/c Hmox1+/+ and Hmox1−/− mice was evaluated by TUNEL (green) (A) and by detecting cleaved caspase-3 (red) (B) at 60 days after M. avium infection. Nuclei were stained with DAPI (blue). Bar, 100 μm. (C) Quantification of the positive cells in panels A and B. Bars represent the average + standard deviation for each group. *, P < 0.05; ***, P < 0.001.
