Table 4.

cagA expression in coculture and patient data

Strain ID	cagA expression in coculture systema	Region risk levelb	MLST typec	Histopathology score of original patientd
PZ5004	5.88 ± 1.07	Low	hpAfrica	2.33
PZ5024	5.12 ± 0.18	Low	hpAfrica	2
PZ5026	14.69 ± 0.24	Low	hpEurope	5.25
PZ5056	15.07 ± 0.13	High	hpEurope	4.5
PZ5080	13.81 ± 0.17	High	hpEurope	3.5
PZ5086	15.78 ± 0.28	High	hpEurope	4.6

^acagA expression was analyzed by microarray using the probe designed against cagA for H. pylori J99 (889201). For each strain, the cagA signal was calculated for three independent biological samples, and the average and SD of the normalized and logged values are presented. The Spearman correlation is 0.83, indicating a positive relationship between cagA expression and the histopathological score.

^bH. pylori strains were isolated from regions of Colombia with either high or low risk for the development of gastric cancer.

^cMLST analysis (26) was previously used to characterize the ancestral origin of the H. pylori strains.

^dPreviously published histopathology scores describing the severity of lesions observed in antral gastric tissue from which the H. pylori strains were isolated (26, 27).